God says

There’r lots of people, including me, don’t know the fact that people would suffer extremely pain If they ended their own life. For instance, one would have to experience the pain of leaping down from a tall building for very long time until the day one should die if he or she ending his or her own life in that way.

When we feel unhappy or unsatisfied in our real life, we try ways to end our own life in order to reliefe our pain. However, this is not such a good way to do for the pain will continue and we’ll be creating more pain when we died.

According to God, we will suffer the same pain that we chose to die again and again, day in, day out, until the day we should die. As for what pain we will have to endure, it depends on the way you choose to end your own life.

How shocking! This is information suitable for those who wish to give up their own life to know. Because by knowing this, they might think twice before doing something foolish…. I think. 

If I could have one wish, my wish would be

假如我能擁有一個願望，我的願望將會是……

 If I could have one wish, my wish would be to have a good health in all of my family members. It’s very significant to stay in good shape because without it you will lead an unhappy life.

To take my son Jimmy for example, he is a kid with rare disease called “Angelman Syndrome.” His life is full of pain and hopeless and has to have his family members to help him do everything. So, that explain why good health is so important.

One will be happier, be full of energy and, above all, see things in the positive way when he or she is in good condition. Thus, try to eat healthier food, exercise more and lead your life a healthy way!

Not everything in life can be planned. There are always unpredictable things happen.

Patience, positive attitude, and calm are necessary when encountering great difficulties.

I still have a lot to learn. I get frustrated easily when it comes to deal with all kinds of complicated situations.

About this unpleasant experience of Jimmy's attending elementary school makes me feel a little bit upset. I also learn that maybe it's time for me to be prepared for problems !

Wednesday-June 23, 2008

I find these stories quite interesting 

這些故事真是太有趣了!!! 

CREATING PERFECT RELATIONSHIPS?

世界上沒有十全十美的人，要求太完美可是會活的不快樂的哦!

A person visited the government matchmaker for marriage, SDU, and requested,"I am looking for a spouse. Please help me to find a suitable one. “The SDU officer said, "Your requirements, please.""Oh, good looking, polite, humorous, sporty, knowledgeable, good in singing and dancing. Willing to accompany me the whole day at home during my leisure hour, if I don't go out. Telling me interesting stories when I need companion for conversation and be silent when I want to rest." The officer listened carefully and replied,"I understand you need television.” There is a saying that a perfect match can only be found between a blindwife and a deaf husband, because the blind wife cannot see the faults of the husband and the deaf husband cannot hear the nagging of the wife. Many couples are blind and deaf at the courting stage and dream of perpetual perfect relationship. Unfortunately, when the excitement of love wears off, they wake up and discover that marriage is not a bed of roses. The nightmare begins. --------------------------------------------------------------------------

NO POINTING FINGERS

當你用一隻手指頭指著別人的同時，其他四隻正指著自已…

 A man asked his father-in-law, "Many people praised you for a successful marriage. Could you please share with me your secret?” The father-in-law answered in a smile, "Never criticise your wife for her shortcomings or when she does something wrong. Always bear in mind that because of her shortcomings and weaknesses, she could not find a better husband than you.” We all look forward to being loved and respected. Many people are afraid of losing face. Generally, when a person makes mistaken, he would look around to find a scapegoat to point the finger at. This is the start of a war. We should always remember that when we point one finger at a person, the other four fingers are pointing at ourselves. If we forgive others, others will ignore our mistake too.

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NO OVERPOWERING

江山易改，本性難移…朋友，改變自已比較快啦! 

Many relationships fail because one party tries to overpower another, or demands too much. People in love tend to think that love will conquer all and their spouses will change the bad habits after marriage. Actually, thisis not the case. There is a Chinese saying which carries the meaning that” It is easier to reshape a mountain or a river than a person’s character." It is not easy to change. Thus, having high expectation on changing the spouse character will cause disappointment and unpleasantness. It would be less painful to change ourselves and lower our expectations. -----------------------------------------------------------------------

RIGHT SPEECH

There is a Chinese saying which carries the meaning that” A speech will either prosper or ruin a nation.” Many relationships break off because of wrong speech. When a couple is too close with each other, we always forget mutual respect and courtesy. We may say anything without considering if it would hurt the other party. A friend and her millionaire husband visited their construction site. A worker who wore a helmet saw her and shouted,” I, Emily! Remember me? We used to date in the secondary school." On the way home, her millionaire husband teased her,” Luckily you married me. Otherwise you will be the wife of a constructionworker."She answered, "You should appreciate that you married me. Otherwise, he will be the millionaire and not you. "Frequently exchanging these remarks plants the seed for a bad relationship. -----------------------------------------

TRUST

Trust is a very important factor for all relationships. When trust is broken, it is the end of the relationship. Lack of trust leads to suspicion, suspicion generates anger, anger causes enmity and enmity may result in separation. A telephone operator told me that one day she received a phone call. She answered, "Public Utilities Board.” There was silence. She repeated, "PUB.” There was still no answer. When she was going to cut off the line, she heard a lady's voice,"Oh, so this is PUB. Sorry, I got the number from my husband's pocket but I do not know whose number it is.” Without mutual trust, just imagine what will happen to the couple, if the telephone operator answered with just,” Hello..." instead of "PUB". --------------------------------------------------------------------------

PERSONAL PERCEPTION

只要問心無愧，用不著太在乎別人說什麼… 不然豈不是會活的太辛苦了嗎?   

Different people have different perception. One man's meat could be another man's poison. A couple bought a donkey from the market. On the way home, a boy commented,” Very stupid. Why neither of them rides on the donkey?” Upon hearing that, the husband let the wife ride on the donkey. He walked besides them. Later, an old man saw it and commented,” The husband is the head of family. How can the wife ride on the donkey while the husband is on foot?” Hearing this, the wife quickly got down and let the husband ride on the donkey. Further on the way home, they met an old Lady. She commented,” How can the man ride on the donkey but let the wife walk. He is no gentleman."The husband thus quickly asked the wife to join him on the donkey. Then, they met a young man. He commented,” Poor donkey, how can you hold up the weight of two persons. They are cruel to you.” Hearing that, the husband and wife immediately climbed down from the donkey and carried it on their shoulders. It seems to be the only choice left. Later, on a narrow bridge, the donkey was frightened and struggled. They lost their balance and fell into the river. "You can

never have everyone praise you nor will everyone condemn you.” Never in the past, not at present, and never will be in the future. Thus, do not be too bothered by others words if our conscience is clear."  

Angelman syndrome deficits rescued in mice

Edwin Weeber, Ph.D., and colleagues used a rotarod (pictured here) to test motor coordination in mice with a genetic "rescue " of Angelman syndrome. Click here for more information.

Children with Angelman syndrome are often seen laughing and smiling, but this cheerful demeanor masks serious neurological problems — mental retardation, movement problems and seizures.

New research in mice, however, suggests that many of these deficits could be alleviated.

Edwin Weeber, Ph.D., and colleagues reversed the neurological deficits in a mouse model of Angelman syndrome by preventing the inhibition of CaMKII, an enzyme highly expressed in brain regions affected by Angelman syndrome.

The results, which appear in the March issue of Nature Neuroscience (currently available online), reveal an important part of the mechanism underlying the condition and point to potential therapeutic targets for treating these symptoms.

Edwin Weeber, Ph.D. Click here for more information.

Angelman syndrome, which affects approximately one in 15,000 children, is a debilitating neurological disorder characterized by mental retardation, severely limited speech, and movement and balance problems.

In 1997, researchers determined that Angelman syndrome was caused by a mutation in a single gene, called UBE3A. They subsequently developed a mouse model of Angelman syndrome by mutating this gene.

But the finding was baffling, said Weeber, because UBE3A is a "housekeeping" gene, meaning that it broadly regulates cellular processes not particularly specific for any of the neurological deficits seen in these children. Specifically, the protein encoded by UBE3A "tags" other proteins for degradation by the cellular "garbage disposal," the proteasome.

"The most difficult thing to rationalize was that this housekeeping gene — which nobody thought did anything — caused severe mental retardation," said Weeber, an assistant professor of Molecular Physiology and Biophysics and Pharmacology and senior author on the study.

"So we started trying to identify some of the protein's molecular targets."

In the process, Weeber and colleagues identified an abnormality in the Angelman syndrome mouse model — changes in an enzyme called calcium/calmodulin-dependent protein kinase II (CaMKII), which is important in the cellular processes that underlie learning and memory.

They found that, in Angelman syndrome, CaMKII activity was reduced due to an inhibitory chemical modification (phosphorylation). Because of CaMKII's prominent role in neuronal function, Weeber suspected that this might account for many of the neurological deficits seen in Angelman syndrome children.

Fortuitously, one of Weeber's colleagues — Ype Elgersma, Ph.D., at Erasmus Medical Center in Rotterdam, Netherlands — had created a mouse with a mutation that prevented this inhibition of CaMKII.

The researchers decided to breed the Angelman mice with the CaMKII mutant mice to see if counteracting the CaMKII inhibition would alleviate the neurological problems.

The researchers then ran the resulting "double mutants" through a battery of neurological and cognitive tests.

Angelman mice performed poorly on learning and memory tasks and displayed impaired motor coordination.

The double mutants, however, showed normal learning and memory and motor coordination. And while the Angelman mice were also prone to seizures, the double mutants showed very low seizure susceptibility.

Weeber was surprised by the robust results. "We thought we might rescue some of the deficits that we saw in the mouse model," he said. "We had no idea that we were going to rescue basically everything."

Although impossible to apply the genetic engineering used in the current study to correct these deficits in mice to humans, Weeber thinks that the findings may point to new therapeutic targets for the disorder.

"It's very conceivable that if we can figure out what lies between UBE3A and CaMKII — and if it's a specific path — then that could be a therapeutic target."

But the results may apply more broadly, Weeber said, to other types of mental retardation syndromes that remained unexplained and untreatable.

"There are a lot of mental retardation syndromes that we still don't understand. Maybe the changes in CaMKII associated with Angelman syndrome could be implicated in other mental retardation syndromes as well."

Weeber is also an investigator in the Vanderbilt Kennedy Center for Research on Human Development.